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DynaMatrix

The smartest solution is the one that leaves no trace.

The smartest solution is the one that leaves no trace.

DynaMatrix® is an extracellular matrix (ECM) derived from porcine small intestinal submucosa (4 layers SIS). ECM contains two of the three essential biological components required for healing: matrix scaffold & signals, which include growth factors and ECM cell receptor-mediated binding sites. It retains both the 3-dimensional structure and the signaling proteins found within the material that communicates with the body to help stimulate the natural healing process. The biologic material guides the patient’s soft tissue to form organized tissue, not scar tissue.

    Matrix scaffold

    Signals, which include growth factors and ECM cell receptor-mediated binding sites

    Tissue remodeling

    Because DynaMatrix is more than just collagen, the extra proteins stimulate soft tissue healing and remodeling into natural tissue as the membrane is absorbed.


Stronger Tissue Sooner

DynaMatrix® offers a 3-dimensional scaffold important for host tissue remodeling, while its signaling proteins within the membrane, stimulate the natural healing process2 and facilitate soft tissue healing.

Retains the natural composition of matrix molecules such as collagen (Type I, III, IV, VI), glycosaminoglycans (hyaluronic acid), glycoproteins (fibronectin) and growth factors1,2

Regulates cell adhesion, migration, division and differentiation3,4,5

Facilitates angiogenesis6 

Easy Handling & Bioactive Design

Combines substantial strength and flexible handling when hydrated

Both sides of DynaMatrix® can be used interchangeably


SIS can be left exposed for tension-free closure

Drapes easily and flexible enough to be cut, rolled, folded, tacked or sutured

Completely remodels into strong, fully vascularized tissue 7,8

References

1. Hodde J, Janis A, Ernst D, Zopf D, Sherman D, Johnson C. Effects of sterilization on an extracellular matrix scaffold: part I. Composition and matrix architecture. J Mater Sci Mater Med. 2007 Apr;18(4):537-43.

2. Hodde JP, Ernst DM, Hiles MC. An investigation of the long-term bioactivity of endogenous growth factor in OASIS Wound Matrix. J Wound Care. 2005 Jan;14(1):23-5.

3. Lindberg K, Badylak SF. Porcine small intestinal submucosa (SIS): A bioscaffold supporting in vitro primary human epidermal cell differentiation and synthesis of basement membrane points. Burns 2001; 27:254-266.

4. Badylak S, Liang A, Record R, Tullius R, Hodde J. Endothelial cell adherence to small intestinal submucosa: An acellular bioscaffold. Biomaterials 1999; 20: 2257-2263.

5. Badylak SF, Park K, Peppas N, McCage G, Yoder M. Marrow-derived cells populate scaffolds composed of xenogeneic extracellular matrix. Exp Hematol 2001; 19: 1301-1218.

6. Nihsen ES, Johnson CE, Hiles MC. Bioactivity of small intestinal submucosa and oxidized regenerated cellulose/collagen. Adv Skin Wound Care 2008; 21:479-486.

7. Rice RD, Ayubi FS, Shaub ZJ, Parker DM, Armstrong PJ, Tsai JW. Comparison of Surgisis, Alloderm, and Vicryl Woven Mesh Grafts for abdominal wall defect repair in an animal model. Aesthet Plast Surg. 2010;34:290-296.

8. Nevins M, Nevins ML, Camelo M, Camelo JM, Schupbach P, Kim DM. The Clinical Efficacy of DynaMatrix Extracellular Membrane in Augmenting Keratinized Tissue. Int J Periodontics Restorative Dent. 2010 Apr;30(2):151-61. 

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